Florence · Self-guided audio walk

Tornabuoni and Santa Maria Novella

A short walk across Florence's elegant western edge, from a painted vault to the perfumed rooms of the world's oldest pharmacy.

  • 5Stops
  • 1.2 kmDistance
  • 20+ minTime
Tornabuoni and Santa Maria Novella

Photo by Greenesol on Wikimedia Commons

This walk stays on the refined western edge of Florence, where the city's richest families built their palaces and their chapels.

You begin at the Dominican church of Santa Maria Novella, home to Masaccio's Holy Trinity, the fresco that taught painters how to fake depth, and to Ghirlandaio's Tornabuoni Chapel. A few steps away sits the Officina Profumo-Farmaceutica di Santa Maria Novella, still making rose water, colognes, and herbal remedies in rooms first used by friars in 1221. Then you follow Via de' Tornabuoni past the rusticated bulk of Palazzo Strozzi and into Palazzo Spini Feroni, where the Ferragamo museum tells the story of shoes that carried Hollywood and Italian craft together. The walk ends at Santa Trinita, where Ghirlandaio's Sassetti Chapel sets the life of Saint Francis among the bankers and streets of fifteenth-century Florence.

Hear it on the street

Get the turn-by-turn audio guide in the app. The narration plays itself as you reach each stop, hands-free and offline.

Stop by stop

The route

Interactive map of the route. The full stop list below works without it.

Basilica di Santa Maria NovellaMust see

Photo by Txllxt TxllxT on Wikimedia Commons

Basilica di Santa Maria Novella

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The Dominican church whose frescoes taught Florence to paint depth, from Masaccio's Holy Trinity to Ghirlandaio's Tornabuoni Chapel.

You're standing before the Dominican church of Santa Maria Novella, begun in 1279 and consecrated in 1420. The lower half of the facade is medieval stone; the upper half, with its clean marble geometry, was finished by Leon Battista Alberti around 1470, and it became the pattern for church fronts across the Renaissance. Step inside and walk halfway up the left aisle. There, in the third arcade, hangs Masaccio's Holy Trinity, painted around 1427.

It is often called the first painting to use true linear perspective, and its barrel vault seems to open a real hole in the wall. Beneath the painted Christ sits a skeleton on a stone ledge, with the inscription, I was once what you are, and what I am you will become. Then turn toward the high altar. The Tornabuoni Chapel, the largest in the church, carries Ghirlandaio's frescoes of the lives of the Virgin and John the Baptist, painted from 1485 to 1490.

Look for the crowds of Florentines standing inside the biblical scenes; a young Michelangelo is said to have worked here as an apprentice.

≈2 min walk to the next stop
Officina Profumo-Farmaceutica di Santa Maria NovellaLocal pick

Photo by Moon rabbit 365 on Wikimedia Commons

Officina Profumo-Farmaceutica di Santa Maria Novella

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The oldest pharmacy in the world, still selling rose water and colognes from rooms the Dominican friars first used in 1221.

Leave the piazza and turn onto Via della Scala. At number 16 you'll find the Officina Profumo-Farmaceutica di Santa Maria Novella, the oldest pharmacy in the world. Dominican friars began compounding remedies here in 1221, when they first settled at the church behind you, and the rooms have stayed in continuous use ever since. Push open the door and the noise of the city drops away.

The space still holds its marble counters, its vaulted ceilings, and its gilded ceiling from the 1600s. This is where the friars distilled rose water for medicines and, later, for perfume, and where they brewed the citrusy Acqua della Regina, the water of the queen, for Catherine de' Medici before she left for France. In 1612 the shop opened to the public, and Grand Duke Ferdinand II later named it the Foundry of His Royal Highness. The soaps, colognes, and elixirs on the shelves are still made here today.

Breathe in, then step back out and turn south toward Via de' Tornabuoni.

≈8 min walk to the next stop
Palazzo StrozziMust see

Photo by Armin Kleiner on Wikimedia Commons

Palazzo Strozzi

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The rusticated stone palace that one Medici rival built to outdo them, with a courtyard anyone can step into.

You've reached Palazzo Strozzi, the great block of rusticated stone at the corner of Via Tornabuoni and Via Strozzi. Filippo Strozzi the Elder returned to Florence in 1466 after twenty-five years of exile under the Medici, and he wanted a house that would announce his family's comeback. He spent from 1473 to 1489 buying and demolishing the smaller buildings on this corner to clear the site. The foundation stone went down at dawn on the sixth of August 1489, timed by an astrologer so that the sign of Leo was rising, a promise that the palace would last forever.

Work on the facade, with its rough stone that lightens as it climbs, continued after Filippo died in 1491 and finished in 1538. Cosimo I de' Medici confiscated the palace that same year and kept it from the family for three decades. Today it holds a contemporary art foundation and a cafe, but you can simply step through the door into the colonnaded courtyard, designed by Simone del Pollaiolo, called Il Cronaca. It is free to enter, and it gives you the cool, ordered calm a Florentine palace was built around.

≈4 min walk to the next stop
Free preview ends here · stops 4 to 5 continue in the app

Museo Salvatore Ferragamo

The shoe museum inside Gothic Palazzo Spini Feroni, tracing a shoemaker's path from a poor Neapolitan town to Hollywood.

in app

Basilica di Santa Trinita

The Vallombrosan church where Ghirlandaio's Sassetti Chapel sets the life of Saint Francis among the bankers and streets of his own Florence.

in app
Good to know

Before you go

What is free on this walk?

The Officina Profumo-Farmaceutica di Santa Maria Novella is free to enter and browse, and the courtyard of Palazzo Strozzi is open to anyone. The church and the Strozzi exhibitions sell their own tickets.

When is the best time to go?

A weekday late morning puts the pharmacy and the two churches at their quietest, and Via de' Tornabuoni is at its best before the shops fill in the afternoon.

Provenance · last verified August 20, 2026

Built from the Wayside route itself: the stops, their order, and the walk between them.

Photo by Greenesol on Wikimedia Commons · CC BY-SA 4.0

Photo by Txllxt TxllxT on Wikimedia Commons · CC BY-SA 4.0

Photo by Moon rabbit 365 on Wikimedia Commons · CC BY-SA 4.0

Photo by Armin Kleiner on Wikimedia Commons · CC BY-SA 4.0

Photo by Joseph Quam on Unsplash

Photo by David Jones on Openverse · CC BY 2.0

Photo by Alexandra Smielova on Unsplash

Photo by Txllxt TxllxT on Wikimedia Commons · CC BY-SA 4.0

Photo by Yair Haklai on Wikimedia Commons · CC BY-SA 4.0

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